What Are Amines and Amine Intolerance?
Biogenic amines are naturally occurring compounds in many foods that form when protein-rich items age or undergo fermentation. Common examples include histamine, tyramine, and serotonin. For most people, these amines are broken down efficiently by enzymes in the body, such as diamine oxidase (DAO). However, those with a deficiency or inefficiency in these enzymes may experience an over-accumulation of amines, leading to an intolerance.
Unlike an allergy, which involves an immune system response, an intolerance is a metabolic issue. Symptoms can vary widely but often include headaches, flushing, skin rashes, and digestive upset. A low amine diet is a dietary strategy that reduces the intake of amine-rich foods to help mitigate these symptoms. The key principle is to consume the freshest, least processed foods possible, as amine levels increase with aging, ripening, and fermentation.
Core Principles for a Low Amine Diet
Following a low amine diet requires a shift in how you shop, cook, and store food. Here are some fundamental guidelines:
- Prioritize Freshness: The fresher the food, the lower its amine content is likely to be. Buy groceries frequently in smaller amounts and eat food shortly after purchase. For meat, freezing it immediately upon purchase can help prevent amine buildup.
- Avoid Fermented and Aged Foods: These are the most significant sources of amines. Stay away from aged cheeses, fermented soy products (like soy sauce and miso), sauerkraut, and cured meats.
- Read Food Labels Carefully: Preservatives, food dyes, and other additives can sometimes contain or release amines. Opt for products with simple, recognizable ingredients.
- Control Cooking Methods: Boiling, steaming, and baking are preferred cooking methods, as frying and grilling can increase amine levels.
- Manage Leftovers: Leftovers can accumulate amines over time. It is best to eat food immediately after cooking. If you must have leftovers, freeze them immediately rather than refrigerating for an extended period.
Low Amine Food Lists
Here is a breakdown of foods that are generally considered low in amines and safe to include in your diet. Note that individual tolerance can vary, so it's always best to monitor your own reactions.
Low Amine Fruits
- Apples (except overly ripe)
- Apricots
- Cantaloupe
- Mangoes
- Peaches
- Pears (the only fruit where amines do not increase as they ripen)
- Berries (except strawberries)
Low Amine Vegetables
- Asparagus
- Beets
- Broccoli and cauliflower
- Carrots (cooked)
- Cucumbers (peeled)
- Green beans
- Lettuce (any kind)
- Onions (cooked)
- Peppers (any color)
- Pumpkin and squash
- Zucchini (peeled)
Low Amine Proteins
- Freshly cooked meat and poultry (chicken, beef, lamb)
- Fresh or individually quick-frozen fish (cod, hake, trout)
- Eggs (especially yolks)
- Mild, un-aged cheeses (cottage cheese, fresh mozzarella, ricotta)
- Lentils and most peas (in moderation)
Low Amine Grains, Fats, and Other Items
- Rice (all varieties) and quinoa
- Corn and corn products
- Oats and plain rice cereal
- Plain pasta and white bread (unleavened is best)
- Vegetable oil, coconut oil, grapeseed oil
- Herbs (parsley, basil, oregano) and mild spices
- Honey and maple syrup
High Amine Foods to Avoid
To effectively manage symptoms, it is crucial to avoid or significantly limit foods known to be high in amines. These items are generally processed, fermented, or aged.
High Amine Foods to Avoid List
- Fermented and aged foods: Aged cheeses (cheddar, Swiss, Parmesan), yogurt, kefir, kombucha, sauerkraut, pickles, miso, and soy sauce.
- Processed and cured meats: Salami, sausages, deli meats, bacon, canned meats, and ham.
- Fish: Canned fish (tuna, sardines), smoked or pickled fish, and certain dark meat fish.
- Certain fruits and vegetables: Tomatoes, spinach, eggplant, avocado, overripe bananas, citrus fruits, and dried fruits.
- Leftovers: Meat and other protein-rich foods stored in the refrigerator can develop high amine levels.
- Alcoholic beverages: Especially red wine and beer.
- Chocolate and cocoa: High in amines and often a trigger.
Comparison of Low vs. High Amine Foods
| Food Category | Low Amine Options | High Amine Options (Avoid) |
|---|---|---|
| Protein | Freshly cooked chicken, fish (cod, trout), eggs, mild cheeses (mozzarella) | Cured meats (salami, ham), aged cheeses (cheddar, parmesan), canned fish (tuna), leftovers |
| Fruits | Apples, peaches, pears, mangoes, cantaloupe, most berries | Citrus fruits, ripe bananas, dried fruits, strawberries, pineapple, papaya |
| Vegetables | Broccoli, cauliflower, carrots, lettuce, cucumbers, potatoes, zucchini | Tomatoes, spinach, eggplant, avocado, pickled vegetables |
| Grains | Rice, quinoa, oats, plain bread, corn tortillas | Yeast-leavened bread (sometimes), cereals with nuts or dried fruit |
| Fats/Oils | Vegetable oil, coconut oil, simple dressings | Olive oil (for some), soy sauce, fish sauce, aged vinegar, packaged dressings |
| Beverages | Water, herbal teas, fresh pear juice | Alcohol (wine, beer), fruit juices (except pear), coffee |
Sample Low Amine Meal Ideas
- Breakfast: Oatmeal made with fresh pasteurized milk or almond milk, topped with peeled apple slices and cinnamon. A cooked egg yolk omelet with shredded carrots and zucchini is another option.
- Lunch: A salad with fresh lettuce, cucumber, bell peppers, and freshly cooked chicken or beef. Use a simple dressing of vegetable oil, salt, and herbs.
- Dinner: Baked cod with roasted root vegetables like carrots, parsnips, and sweet potatoes. Season with salt and dried herbs like parsley.
- Snack: Plain rice cakes with cottage cheese, or a smoothie made with fresh peaches and almond milk.
Final Thoughts
Embracing a low amine diet can be a journey of discovery, helping you understand your individual food sensitivities. The core takeaway is to focus on fresh, unprocessed ingredients and manage how your food is prepared and stored to minimize amine content. While the diet can seem restrictive at first, many delicious and satisfying meals can be created by prioritizing simple, fresh ingredients. Working with a dietitian can also provide personalized guidance to ensure your dietary needs are met. By paying close attention to your body's responses, you can tailor the diet to your specific needs and find relief from your symptoms.
For more information on the principles of eliminating trigger foods, you can refer to guidance from sources like the Australasian Society of Clinical Immunology and Allergy.