A Closer Look at Cashew Allergy and Its Dangers
Cashew nut allergy is one of the most common and severe tree nut allergies, often posing a more significant risk of anaphylaxis than peanut allergies, particularly in children. This heightened risk is a major reason why those with known tree nut allergies should approach cashews with extreme caution or avoid them altogether. The immune system mistakenly identifies the proteins in the cashew as a threat, triggering a serious allergic reaction that can be life-threatening.
Cross-Reactivity and Severe Reactions
- Cross-Reactivity: Individuals allergic to other tree nuts, like pistachios, may also have a cross-reaction to cashews due to similar protein structures. It is essential for allergic individuals to be tested for potential cross-reactivity and consult an allergist for proper guidance.
 - Anaphylaxis: Symptoms of an allergic reaction can include hives, swelling, wheezing, digestive distress, and in severe cases, anaphylaxis. Anaphylaxis is a medical emergency characterized by airway constriction, a rapid drop in blood pressure, and shock. Anyone with a cashew allergy should carry an epinephrine auto-injector (EpiPen) and know when to use it.
 
The Problem with Raw Cashews: Urushiol Toxicity
Most consumers are unaware that truly raw, unprocessed cashews are toxic and should never be consumed. The cashew nut is encased in a hard shell that contains urushiol, a toxic oil also found in poison ivy, poison oak, and poison sumac. Contact with urushiol can cause severe skin rashes and irritation. The "raw" cashews available in stores have been steamed or roasted to remove this toxic shell oil, rendering them safe for consumption. People with a sensitivity to poison ivy may be particularly susceptible to adverse reactions from inadequately processed cashews.
Kidney Health and Oxalate Content
Cashews contain a relatively high amount of oxalates, natural compounds that can contribute to the formation of kidney stones in susceptible individuals. For people with a history of calcium oxalate kidney stones, or those with kidney disease, consuming too many high-oxalate foods like cashews can worsen their condition. While moderate consumption may be acceptable, individuals with pre-existing kidney problems should consult a doctor to determine a safe intake level.
Oxalate Content of Common Nuts
To help visualize the difference, here is a comparison table of the approximate oxalate content in various nuts, based on available research:
| Nut Type | Oxalate Content (mg per 1 oz / 28g serving) | Note | 
|---|---|---|
| Almonds | ~122 mg | Very high | 
| Cashews | ~49-64 mg | High | 
| Hazelnuts | ~62 mg | High | 
| Walnuts | ~49 mg | Low to moderate | 
| Macadamia Nuts | ~11 mg | Low | 
| Pecans | ~28 mg | Moderate | 
Digestive Issues and the High-FODMAP Profile
Cashews are classified as a high-FODMAP food due to their content of fructans and galactans. For individuals with Irritable Bowel Syndrome (IBS), consuming cashews can trigger uncomfortable symptoms such as bloating, gas, and diarrhea. The gut of a person with IBS has trouble absorbing these short-chain carbohydrates, leading to fermentation and digestive upset.
Strategies for Digestive Sensitivity
- Portion Control: Limiting intake to a very small amount (e.g., less than 15 grams) may help some individuals manage symptoms.
 - Soaking or Roasting: Some sources suggest soaking or roasting can reduce phytates, which can improve digestibility, though it does not eliminate the FODMAP content.
 - Avoid Raw: Raw cashews are particularly high in FODMAPs and should be avoided entirely during the elimination phase of a low-FODMAP diet.
 
Medication Interactions and Other Risks
Cashews are rich in magnesium, and consuming them in large quantities can potentially interfere with certain medications. This includes:
- Diabetes Medications: Excessive intake may increase blood sugar levels, potentially reducing the effectiveness of anti-diabetic drugs like insulin. Diabetics should closely monitor their blood sugar and consult their doctor before adding significant amounts of cashews to their diet.
 - Antibiotics: Magnesium can bind to some antibiotics (e.g., quinolones like ciprofloxacin), preventing proper absorption.
 
Furthermore, high-calorie, high-fat foods like cashews can lead to weight gain if consumed in excess. Salted varieties, in particular, should be limited to prevent excessive sodium intake, which can contribute to high blood pressure. For those with upcoming surgery, it is often recommended to stop eating large amounts of cashews at least two weeks prior to manage blood sugar levels.
Conclusion
While a nutritious snack for many, cashews are not suitable for everyone. Individuals with a tree nut allergy, especially to cashews or pistachios, should avoid them completely due to the high risk of severe anaphylaxis. Those prone to kidney stones or with pre-existing kidney disease must monitor their intake due to high oxalate levels. People with IBS should be cautious of cashews' high FODMAP content and limit portions to avoid digestive distress. Lastly, individuals with diabetes or on certain medications should consult a healthcare provider regarding interactions, and everyone should be mindful of portion sizes to prevent weight gain and excessive sodium intake from salted products. Moderation and mindful eating are key to enjoying cashews safely for those without contraindications.