Understanding the difference between A1 and A2 milk
At its core, the reason why people buy A2 milk comes down to a small, yet significant, genetic difference in dairy cows. Most commercially available milk today comes from cows, like Holstein Friesians, that produce a combination of A1 and A2 beta-casein protein. However, the A2 protein is the older, original variant and is still produced by some cow breeds, like Jerseys and Guernseys, as well as humans, sheep, and goats. The key distinction lies in how these two protein variants are broken down during digestion.
The role of BCM-7 in digestive discomfort
When the A1 beta-casein protein is digested, it can release a peptide called beta-casomorphin-7 (BCM-7). BCM-7 is an opioid-like compound that has been linked to a variety of gastrointestinal symptoms, including bloating, gas, and abdominal discomfort in some people. By contrast, the A2 protein does not release BCM-7 during digestion. This crucial difference in the digestive process is the primary reason many individuals sensitive to regular milk find relief when they switch to A2 milk, as their discomfort may be linked to the A1 protein rather than lactose.
A2 milk's potential impact on gut health and beyond
Research on A2 milk's broader effects is still emerging, but some studies point to additional health benefits beyond just easing digestion. For instance, a 2025 study on individuals with GI discomfort found that A2 milk consumption significantly altered their gut microbiota composition, promoting beneficial microbes like Bifidobacterium and Blautia. This shift was negatively correlated with fecal calprotectin, an inflammatory marker, suggesting A2 milk may have anti-inflammatory effects in the gut. The study's authors theorize that A2 milk supports better gut health, which is a major factor in overall immune function.
Potential benefits of A2 milk
- Easier digestion: Reduced symptoms of gas, bloating, and abdominal pain for those sensitive to the A1 protein.
- Improved gut microbiome: Some research shows that A2 milk can increase the abundance of beneficial bacteria in the gut, which may support better digestive and immune health.
- Reduced gut inflammation: Studies suggest a link between A1 protein consumption and increased inflammatory markers, which is not seen with A2 milk.
- Rich nutritional profile: A2 milk retains all the same essential nutrients as regular cow's milk, such as calcium, protein, potassium, and vitamin D, without the potential digestive side effects of A1 protein.
- Option for lactose-sensitive individuals: While not lactose-free, many who self-diagnose as lactose intolerant discover their symptoms are actually tied to the A1 protein. These individuals may tolerate A2 milk better.
Nutritional comparison: A2 milk vs. Regular (A1/A2) milk
| Feature | A2 Milk | Regular (A1/A2) Milk |
|---|---|---|
| Beta-Casein Protein | Contains only A2 beta-casein. | Contains both A1 and A2 beta-casein. |
| Digestion | Easier for some sensitive individuals; does not release BCM-7. | Digestion can release BCM-7, potentially causing discomfort. |
| Macronutrients | Same amount of protein, fat, and calories (depending on variety). | Same amount of protein, fat, and calories (depending on variety). |
| Micronutrients | Same amount of calcium, potassium, and vitamins. | Same amount of calcium, potassium, and vitamins. |
| Lactose Content | Contains lactose (unless labeled otherwise). | Contains lactose. |
| Suitability for Allergies | Not suitable for those with a cow's milk protein allergy. | Not suitable for those with a cow's milk protein allergy. |
Making the switch to A2 milk
For those who experience digestive issues after drinking regular cow's milk, switching to A2 milk is a worthwhile experiment. It is important to remember that A2 milk is not lactose-free, so it will not address symptoms stemming from a true lactose intolerance. However, many people confuse A1 protein sensitivity with lactose intolerance, and A2 milk can provide a dairy option without the associated discomfort. Because A2 milk comes from specially-selected herds of cows that are genetically tested to produce only the A2 protein, it is typically more expensive than regular milk. The increased cost reflects the specialized farming and testing processes required to ensure its purity. Consumers interested in learning more about A2 milk and its production can find a wealth of information from reputable sources and research, such as the National Institutes of Health.
The bottom line
Ultimately, the choice to buy A2 milk is a personal one, often motivated by the desire to alleviate digestive discomfort while continuing to enjoy the nutritional benefits of dairy. For individuals who have experienced unpleasant symptoms from regular milk, a trial of A2 milk may reveal that the A1 protein was the real issue. With the same nutritional profile as conventional milk but without the A1 protein, A2 milk offers a promising solution for those seeking a gentler dairy option.