Does Gelatin Affect Blood Pressure? Exploring the Health Connection

October 21, 2025 •

5 min read

Research in animal models suggests that certain gelatin-derived peptides have a significant antihypertensive effect, leading to a reduction in blood pressure. This exciting finding raises the question: Does gelatin affect blood pressure in humans and what should consumers know about this popular supplement?

Quick Summary

Gelatin's impact on blood pressure varies depending on the form. While studies show hydrolyzed gelatin peptides may have a blood-pressure-lowering effect by inhibiting the ACE enzyme, processed gelatin desserts can contain high sodium and sugar levels that negatively affect cardiovascular health.

Key Points

Gelatin peptides may lower blood pressure: Animal studies show that specific peptides derived from gelatin can act as ACE inhibitors, which reduces blood pressure.
Plain gelatin is preferable to flavored versions: Unflavored gelatin powder is low in sodium and sugar, while processed gelatin desserts are high in both, which is detrimental to blood pressure.
Human research is limited: Most evidence for the antihypertensive effect of gelatin peptides comes from animal or lab studies, and more human trials are needed to confirm the results.
Collagen peptides are likely the active form: Hydrolyzed gelatin, or collagen peptides, is the most bioavailable form and contains the specific peptides studied for blood pressure benefits.
Gelatin offers other health benefits: Beyond potential blood pressure effects, gelatin provides amino acids like glycine that support gut health and reduce inflammation.
A balanced diet is essential: Gelatin supplementation should complement a heart-healthy diet, not replace proper nutrition and medical management for hypertension.

The Complex Relationship Between Gelatin and Blood Pressure

When we consider the nutritional impact of a food or supplement, it is crucial to understand its composition and the form in which it is consumed. Gelatin, derived from collagen, is a protein-rich substance containing a unique amino acid profile. Its effect on blood pressure is not a simple yes or no answer but depends on several factors, including whether it is a pure, unflavored powder or a highly processed dessert. The most promising research into gelatin's cardiovascular effects focuses on its bioactive peptides.

The Antihypertensive Potential of Gelatin Peptides

Several studies, particularly in animal models, have explored the antihypertensive effects of bioactive peptides derived from hydrolyzed collagen and gelatin. These peptides act as natural inhibitors of the Angiotensin-Converting Enzyme (ACE), a key regulator of blood pressure.

ACE Inhibition: The renin-angiotensin system (RAS) is a critical hormonal system that regulates blood pressure. A key step involves ACE, which converts angiotensin I into the potent vasoconstrictor angiotensin II. By inhibiting ACE, gelatin peptides can reduce the production of angiotensin II, leading to the relaxation of blood vessels and a decrease in blood pressure.
Animal Studies: Numerous studies on spontaneously hypertensive rats (SHRs) have demonstrated significant blood pressure reduction after consistent administration of bovine bone gelatin peptides (BGP). Researchers found that BGP treatment downregulated the negative ACE/angiotensin II/AT1R pathway while upregulating the beneficial Angiotensin II/AT2R pathway, contributing to lower blood pressure and improved lipid metabolism.
Source Variation: Studies have identified potent antihypertensive peptides from a variety of sources, including bovine, porcine, and marine gelatin (like fish skin). This indicates that the effect is not limited to one type of animal source.

Distinguishing Between Gelatin Forms

The form in which gelatin is consumed is perhaps the most important factor for blood pressure. A pure, unflavored gelatin powder is very different nutritionally from a sweetened, store-bought gelatin dessert. This distinction is critical for anyone managing their blood pressure.

Plain Gelatin Powder:

Pure, protein-rich supplement with minimal sodium and no sugar.
Contains the collagen-derived peptides that have shown promise in research.
Free from additives that could negatively affect cardiovascular health.

Flavored Gelatin Desserts:

Often contain high amounts of added sugar and artificial flavorings.
Can have significant sodium content, which is a well-established risk factor for high blood pressure.
The processed ingredients can negate any potential benefit from the gelatin itself.

Collagen Peptides (Hydrolyzed Gelatin):

More readily absorbed by the body due to enzymatic breakdown.
Likely the form most similar to the bioactive peptides used in successful animal studies.
Often used as a supplement to target specific health benefits.

Nuances in Research and Potential Considerations

While the animal studies on hydrolyzed gelatin are promising, several considerations are important for humans.

Need for Human Trials: Most of the definitive antihypertensive evidence comes from lab or animal studies, not human trials. While the mechanism is understood, confirming the same effects in humans requires more robust research.
Potential Negative Findings: One older study in genetically modified mice showed that while gelatin reduced total cholesterol, it also reduced beneficial HDL cholesterol, potentially accelerating atherosclerosis. This was a highly specific study, but it highlights the need for a balanced view and further research, especially considering the source of the gelatin and the presence of other nutrients.
Medical vs. Dietary Use: It is important not to confuse dietary gelatin with its medical application. Gelatin is sometimes used in hospital settings as a plasma volume expander to increase blood pressure in cases of hypovolemic shock, but this is an intravenous application and not relevant to dietary intake.
Overall Dietary Context: The potential benefits of gelatin do not replace a heart-healthy diet rich in fruits, vegetables, whole grains, and lean protein, and low in sodium and saturated fat. Supplements should be part of a balanced diet, not a substitute for it.

Comparison of Gelatin Forms for Cardiovascular Health


Feature	Plain Gelatin Powder (Unflavored)	Flavored Gelatin Dessert (e.g., Jell-O)
Active Peptides	Contains naturally occurring collagen peptides with potential ACE-inhibitory activity.	Also contains peptides, but the dose is likely lower and effects may be negated by other ingredients.
Sodium Content	Very low to negligible sodium content.	Can be high in sodium, with some products containing up to 350mg per serving, negatively impacting blood pressure.
Sugar Content	Zero grams of sugar.	High in added sugars, which can contribute to weight gain, inflammation, and other cardiovascular risks.
Cardiovascular Impact	Potentially positive or neutral. The low sodium and pure protein profile is beneficial, and peptides may offer specific benefits.	High risk of negative cardiovascular impact due to high sugar and sodium content.
Use Case	As a protein supplement, to make healthy snacks, or to thicken sauces.	As an occasional sweet treat or dessert. Not recommended for daily cardiovascular support.

How to Incorporate Gelatin into a Heart-Healthy Diet

For those interested in exploring the potential benefits of gelatin for blood pressure and overall heart health, focus on pure, unflavored sources. Here are some simple methods:

Make Bone Broth: A rich, natural source of gelatin. Simmering animal bones and connective tissue releases gelatin and its beneficial compounds.
Add to Smoothies: Mix a spoonful of high-quality, unflavored gelatin powder or collagen peptides into your daily smoothie for a protein boost.
Prepare Homemade Gummies: Create your own healthy gummies using gelatin powder, fruit juice, and natural sweeteners to avoid processed sugars and colors.
Thicken Soups and Sauces: A small amount of gelatin can add body to soups and sauces, increasing protein content without compromising flavor.

Conclusion: The Bottom Line on Gelatin and Blood Pressure

Ultimately, does gelatin affect blood pressure? The most direct answer is that research on hydrolyzed gelatin peptides, particularly from animal studies, shows a potential antihypertensive effect by inhibiting the ACE enzyme. The peptides appear to be the active component, suggesting that plain gelatin powder or specific collagen peptide supplements are the most viable options for this benefit.

However, it's crucial to differentiate this from flavored, processed gelatin desserts, which are often high in sugar and sodium and pose a genuine risk to cardiovascular health. While human trials are needed to confirm these effects, incorporating pure, unflavored gelatin or collagen peptides into an otherwise healthy diet is likely safe and may offer ancillary benefits beyond blood pressure, such as improved gut and joint health. Always prioritize a balanced, low-sodium diet and consult a healthcare provider for personalized advice on managing blood pressure.

Visit PubMed to learn more about the role of bovine bone gelatin peptides in hypertension.

Frequently Asked Questions

No, it is not recommended to consume flavored gelatin desserts for blood pressure management. These products are often loaded with sugar and sodium, which can negatively impact cardiovascular health and counteract any potential benefits from the gelatin itself.

Collagen peptides are essentially hydrolyzed gelatin, meaning they are already broken down into smaller, more easily absorbed peptides. The research showing a blood-pressure-lowering effect is based on these specific peptides, making a collagen peptide supplement or hydrolyzed gelatin a more direct source of the active compounds.

Specific peptides within hydrolyzed gelatin have been found to act as natural inhibitors of the Angiotensin-Converting Enzyme (ACE). By blocking this enzyme, the body reduces the production of angiotensin II, a hormone that constricts blood vessels and raises blood pressure.

For pure gelatin, the risks are generally low. However, high doses of supplements could potentially cause minor side effects like mouth sores. Additionally, one animal study showed a potential negative effect on cholesterol balance in a specific context. It's always best to consult with a doctor before starting any new supplement, especially if managing a health condition like hypertension.

No, not all gelatin peptides are the same. Studies show that the specific peptide structure and molecular weight are critical for ACE inhibitory activity. Standard, unhydrolyzed gelatin may not contain the same level of active peptides as specifically developed gelatin hydrolysates.

Use unflavored gelatin powder or collagen peptides. You can add these to bone broths, smoothies, or make homemade, low-sugar gummies. This allows you to gain the potential benefits without the high sugar and sodium content found in processed products.

No, you should never replace prescribed medication with a dietary supplement without consulting your doctor. While gelatin peptides may show promise, they are not a proven cure for hypertension, and relying solely on them could be dangerous.