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Is powdered erythritol safe?

4 min read

According to a 2023 study published in the journal Nature Medicine, higher blood levels of erythritol were associated with an increased risk of heart attack and stroke, raising significant questions about whether powdered erythritol is safe for everyone.

Quick Summary

This article evaluates the safety profile of powdered erythritol, considering its FDA “Generally Recognized as Safe” status alongside recent studies on cardiovascular risk and potential digestive side effects.

Key Points

  • FDA Status: Erythritol has a 'Generally Recognized as Safe' (GRAS) status from the FDA, but recent findings are prompting further review.

  • Cardiovascular Risk: A 2023 study associated high blood erythritol levels with increased risk of heart attack and stroke, though it did not prove causation and involved a high-risk group.

  • Digestive Side Effects: High consumption can lead to bloating, gas, cramping, and diarrhea, though erythritol is typically better tolerated than other sugar alcohols.

  • Dosage Matters: The amount consumed significantly affects both cardiovascular risk (at high concentrations) and digestive comfort.

  • No Difference in Safety: Powdered erythritol has the same chemical composition as its granulated form, so its safety profile is identical; the difference is only in crystal size and texture.

  • Caution for High-Risk Individuals: Those with pre-existing cardiovascular conditions, diabetes, or reduced kidney function should exercise caution and consult a doctor regarding erythritol consumption.

In This Article

What is Powdered Erythritol?

Powdered erythritol is a zero-calorie, zero-carb sugar alcohol that has become a staple for many following keto, diabetic, or low-sugar diets. It is a very fine version of granulated erythritol, produced by fermenting glucose, typically derived from corn or wheat starch, with specific yeasts. This fermentation process creates erythritol crystals, which are then ground into a fine powder, similar in texture to confectioner's sugar. This fine texture makes it ideal for applications that require a smooth finish, such as frostings, glazes, and light, fluffy baked goods. While it is naturally present in small amounts in some fruits like grapes and melons, and fermented foods like cheese, the product sold commercially is industrially produced for wide use.

The FDA's 'Generally Recognized as Safe' Status

The U.S. Food and Drug Administration (FDA) has classified erythritol as a "Generally Recognized as Safe" (GRAS) substance. This classification is based on its long history of use and the fact that most of what is consumed is not metabolized by the body but rather absorbed into the bloodstream and excreted unchanged in the urine. Unlike other sugar alcohols, erythritol is largely absorbed in the small intestine before it can reach the colon and undergo fermentation, which typically reduces the severity of common gastrointestinal side effects. However, this GRAS status has been subject to scrutiny, as companies can self-declare a substance as safe, and the quantities found in many processed foods today are far higher than what would be naturally consumed.

Potential Cardiovascular Risk: The 2023 Study

In 2023, a study published in Nature Medicine by researchers at the Cleveland Clinic generated significant headlines and sparked debate about erythritol's long-term safety. The research, initially seeking unknown compounds linked to heart disease risk, found higher levels of erythritol in the blood of individuals who were at a higher risk of heart attack and stroke. Further testing on human blood platelets and in animal models suggested that erythritol could enhance blood clotting.

It is crucial to understand the context of this study:

  • Observational, not Causal: The primary finding was an association, not a definitive cause-and-effect relationship. Participants in the study cohorts already had existing risk factors for cardiovascular disease, such as diabetes and high blood pressure, which may have confounded the results.
  • High-Dose Intake: In a small follow-up trial, healthy volunteers who consumed a beverage containing 30 grams of erythritol showed blood levels elevated significantly for several days. Thirty grams is a common amount found in a pint of keto ice cream and is much higher than what would be consumed in single-serving uses.
  • Further Research Needed: The study authors and other experts have emphasized the need for more in-depth research to understand the long-term effects on the general population.

The FDA reviewed the 2023 study and confirmed that the observational data did not establish a causal link. The agency continues to monitor new research on erythritol and other sweeteners. Read more about this research from the National Institutes of Health: Erythritol and cardiovascular events.

Common Side Effects: Digestive Discomfort

Though better tolerated than some other sugar alcohols like xylitol, erythritol can still cause digestive issues, particularly at higher doses. The most common side effects include:

  • Bloating
  • Cramping
  • Gas
  • Nausea
  • Diarrhea (especially with doses over 50 grams)
  • Stomach rumbling

Individual tolerance varies significantly. Introducing it gradually and keeping portions moderate can help minimize discomfort. For those with pre-existing gastrointestinal conditions like Irritable Bowel Syndrome (IBS), erythritol, as a FODMAP, may worsen symptoms.

Powdered Erythritol Comparison

Feature Powdered Erythritol Table Sugar Stevia (with Erythritol)
Sweetness 70% of sugar 100% 200-400x sweeter than sugar, diluted with erythritol
Calories Zero (approx. 0.2 cal/g in US) 4 calories per gram Zero calories
Glycemic Index Zero 65 Zero
Dental Impact Non-cariogenic, may inhibit oral bacteria Contributes to cavities Non-cariogenic
Side Effects Dose-dependent GI issues, cooling effect None (in moderation) Potential aftertaste, some GI issues from bulk erythritol
Best For Smooth glazes, frostings, delicate baked goods General baking, desserts, coffee High-intensity sweetness needs, masking stevia's aftertaste

Weighing Risks and Benefits

The safety of powdered erythritol is complex and depends heavily on individual health and consumption habits. For many people, particularly those managing diabetes or seeking low-calorie options, it remains a suitable sugar replacement, as it does not affect blood sugar or insulin levels. Its dental benefits are also well-documented. However, recent cardiovascular research warrants caution, especially for individuals already at risk for heart disease. The large quantities found in some modern processed foods may exceed historically safe consumption levels and require further investigation into their long-term effects. Ultimately, moderation is key, and an informed perspective is essential to balancing the benefits against potential risks.

Conclusion

While regulatory bodies like the FDA have deemed erythritol generally safe, recent scientific findings suggest a more nuanced picture. A 2023 study linking high blood erythritol to cardiovascular events serves as a cautionary flag, particularly for high-risk populations, even if it does not establish causation. Digestive side effects are also a known concern, especially with excessive intake. The texture of powdered erythritol does not alter its safety profile compared to its granulated form. For most healthy individuals in moderation, powdered erythritol is a viable sugar alternative. However, those with pre-existing heart conditions or diabetes should approach high consumption with caution and always consult a healthcare provider. Prioritizing less processed, whole-food alternatives to sweeteners remains a sensible choice for long-term health.

Frequently Asked Questions

While generally considered safe in moderate amounts, recent cardiovascular risk concerns and potential digestive issues mean it is not suitable for everyone. Individuals with pre-existing heart conditions should be especially cautious.

Yes, consuming high amounts of powdered erythritol can cause digestive issues like bloating, gas, and cramping, though it is often better tolerated than other sugar alcohols.

Erythritol has a glycemic index of zero and does not spike blood sugar, making it a popular choice for diabetics. However, recent cardiovascular concerns suggest diabetics, who are already at higher risk for heart issues, should be cautious with high doses.

There is no difference in the safety profile. Both are chemically identical; the only distinction is the particle size, which makes powdered erythritol better for smooth applications like icing.

Studies suggest that dosages above 50 grams, or over 0.8 grams per kilogram of body weight for women and 0.66 grams for men, can cause digestive side effects. The 2023 cardiovascular study involved even higher levels.

No, the study showed an association, not a causal link. It was observational and conducted on a high-risk population, highlighting the need for more research, but not proving that erythritol directly causes cardiovascular events.

Erythritol is only about 70% as sweet as sugar and can have a 'cooling' effect. It is often blended with high-intensity sweeteners like stevia or monk fruit to increase overall sweetness and provide bulk.

References

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Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.