Inside Project Blueprint: A Deeper Look at Bryan Johnson's Supplements
Bryan Johnson's pursuit of biological age reversal through Project Blueprint involves a meticulously controlled diet, exercise regimen, and, notably, a comprehensive supplement protocol. This daily intake consists of dozens of compounds, from over-the-counter vitamins to prescription medications, all chosen and adjusted by a team of medical experts based on his diagnostic test results. To simplify this process and make his regimen more accessible, Johnson and his team developed the Blueprint Stack, a line of proprietary products featuring many of the same ingredients he uses.
The Foundational Blueprint Stack
At the core of Johnson's supplement routine are his custom-formulated Blueprint products, which consolidate many of his daily needs into more manageable servings. These products are designed to support a wide array of health markers, including energy, vitality, cognitive function, and inflammation.
Here are some of the key products in his stack:
- Longevity Mix: A powder blend designed to support vitality and focus, featuring 14 ingredients. Notable components include creatine, ashwagandha, L-lysine, glycine, Ca-AKG, and taurine. Johnson mixes and drinks this first thing in the morning.
- Essential Capsules: These provide a comprehensive multivitamin/multimineral blend with 26 nutrients per serving, including B vitamins, vitamin D3, vitamin E, zinc, and CoQ10. The formula is intended to support sleep, muscle recovery, and overall longevity.
- Essential Softgel: A formulation containing fat-soluble nutrients for eye health, heart health, and antioxidant support. It includes lutein, zeaxanthin, astaxanthin, and vitamins K1 and K2.
- NAC + Ginger + Curcumin: This capsule blend combines three potent ingredients known for their antioxidant and anti-inflammatory properties. It is intended to combat oxidative stress, reduce inflammation, and support liver function.
- Red Yeast Rice + Odor-Free Garlic: A combination to support cardiovascular health and healthy cholesterol levels.
Additional and Prescription Compounds
Beyond his core Blueprint products, Johnson's regimen includes a collection of individual supplements and prescription medications based on specific biomarker data.
- Nootropics and Cognitive Enhancers: To optimize brain function, Johnson takes supplements like NMN (nicotinamide mononucleotide) or NR (nicotinamide riboside), both precursors to NAD+, a coenzyme vital for cellular energy and DNA repair. He also uses L-theanine for calm focus and Alpha-GPC for cognitive support.
- Inflammation and Antioxidants: Compounds like omega-3 fatty acids (EPA/DHA/DPA), aged garlic extract (Kyolic), and the curcumin in his Blueprint stack are critical for reducing chronic inflammation. Other antioxidants like astaxanthin and fisetin are also part of his routine.
- Gut Health: The regimen includes prebiotics (like galactooligosaccharides and inulin) and probiotics (like Lactobacillus acidophilus) to support the gut microbiome.
- Prescription Medications: Johnson takes several prescribed drugs under medical supervision, including Acarbose and Metformin, which are typically used for blood sugar regulation. He was also diagnosed with hypothyroidism and takes Levothyroxine for thyroid management. These highlight that his approach is not purely a supplement stack but a medically managed protocol.
The Role of Data and Precision
Unlike simply following a pre-packaged supplement plan, Johnson's routine is highly dynamic and data-driven. His team of 30+ medical experts and scientists continuously analyze hundreds of biomarkers from his blood, stool, and other tests. This allows for real-time adjustments to his supplement dosages and types, ensuring that his intake is precisely tailored to his body's unique and changing needs.
Comparison of Standard vs. Bryan Johnson's Supplementation
| Feature | Standard Supplementation | Bryan Johnson's Protocol |
|---|---|---|
| Selection | Often based on general health needs, marketing, or trends. | Guided by a team of doctors and scientists based on hundreds of biomarkers. |
| Cost | Varies widely, but typically accessible for the average consumer. | Very high, potentially hundreds to thousands of dollars per month, including tests. |
| Customization | Little to none; one-size-fits-all products. | Extremely personalized, with dosages and supplements adjusted bi-weekly. |
| Goal | General wellness, addressing specific deficiencies. | Radical longevity and biological age reversal. |
| Oversight | Self-managed or based on casual advice. | Medically supervised with frequent lab work and imaging. |
| Inclusion of Prescriptives | Typically excluded, relying solely on over-the-counter products. | Integrates prescription medications like Metformin and Acarbose. |
Is Following Johnson's Regimen Practical?
While the detailed information about what Bryan Johnson's supplements are is public, replicating his exact protocol is impractical and potentially dangerous for most people. The high cost is prohibitive, but more importantly, the regimen is hyper-specific to his individual physiology, which is constantly monitored by medical professionals. Generic emulation could lead to nutrient imbalances, side effects, or dangerous interactions, particularly with his use of prescription drugs. A more sensible approach is to take inspiration from his data-driven method and focus on foundational health strategies.
Conclusion
Bryan Johnson's supplement protocol is a fascinating, if extreme, example of a data-first approach to health optimization. The list of what are Bryan Johnson's supplements is long and complex, reflecting a deep, expensive, and scientifically guided effort to reverse aging. For most people, adopting his methods directly is not feasible or advisable. Instead, the takeaway is the importance of a personalized approach to health, informed by science, and centered on key areas like cellular health, cognitive function, and inflammation. It serves as a reminder that fundamental practices—like a healthy diet, exercise, and adequate sleep—remain the most accessible and effective path to well-being, with supplements playing a supporting role based on individual needs and medical guidance. For more information on Johnson's Blueprint, visit his project website [https://blueprint.bryanjohnson.com/].
