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What is the negative side effect of Tongkat Ali?

4 min read

A 2021 report by the European Food Safety Authority expressed concern that high intakes of tongkat ali could potentially induce DNA damage. This highlights the importance of understanding what is the negative side effect of Tongkat Ali and how to approach its use with caution.

Quick Summary

Tongkat Ali can cause anxiety, insomnia, and digestive issues in some users, with risks including liver injury and drug interactions. Potential DNA damage and high-intake prostate changes in animal studies warrant vigilance.

Key Points

  • Anxiety and Insomnia: Tongkat Ali's hormonal effects can cause restlessness, anxiety, and disrupt sleep, particularly with higher intake.

  • Gastrointestinal Issues: Some users report mild digestive problems such as nausea, abdominal discomfort, and diarrhea.

  • Liver and DNA Concerns: Rare cases of liver injury have been linked to Tongkat Ali, and higher intakes may potentially cause DNA damage.

  • Drug Interactions: The supplement interacts with blood thinners, diabetes medication, blood pressure medication, and immunosuppressants, requiring medical supervision.

  • Quality Control Risks: The supplement market lacks regulation, leading to risks of heavy metal contamination and adulteration with other drugs.

  • Specific Contraindications: Pregnant women, those with hormone-sensitive cancers, and individuals with liver, kidney, or heart disease should avoid Tongkat Ali.

In This Article

Understanding Tongkat Ali: Beyond the Benefits

Tongkat Ali, also known as Eurycoma longifolia or Long Jack, has gained significant popularity as a herbal supplement, largely for its purported benefits related to testosterone levels, libido, and athletic performance. Originating from Southeast Asia, its root has been used in traditional medicine for centuries. However, like any potent supplement, it is not without potential drawbacks. A comprehensive look at the risks is necessary for informed use, especially since the supplement market is largely unregulated, leading to issues with quality control, heavy metal contamination, and mislabeling.

Common Mental and Behavioral Side Effects

One of the most frequently reported negative effects of Tongkat Ali relates to its impact on mood and behavior. The testosterone-boosting properties, while desired by some, can disrupt hormone balance and lead to psychological symptoms in others. These effects are often anecdotal, but consistently reported, pointing to a need for individual users to monitor their reactions closely.

  • Anxiety and Restlessness: Some individuals experience heightened feelings of anxiety and restlessness. This may be due to the supplement's stimulating effects and its potential to increase adrenaline production, especially at higher intakes.
  • Insomnia: Because it can increase energy levels, taking Tongkat Ali in the afternoon or evening can disrupt sleep patterns and cause insomnia.
  • Increased Aggression and Irritability: Changes in hormone levels can manifest as increased aggression or irritability in some users.

Gastrointestinal and Physical Adverse Effects

For some, Tongkat Ali can cause digestive discomfort and other physical reactions. These side effects are generally mild and more common when starting supplementation or at higher intakes.

  • Nausea and Abdominal Discomfort: Mild stomach issues like nausea and general abdominal discomfort have been noted in some studies.
  • Diarrhea: Digestive upset can also result in diarrhea.
  • Headaches and Itching: Less frequently, users report experiencing headaches and rashes or itching.

Significant Health Concerns and Long-Term Risks

While short-term studies at conventional intakes suggest the supplement is relatively safe for most healthy adults, there are serious risks to consider, particularly with long-term use, higher intakes, and in specific populations.

  • Liver Injury: Isolated reports of clinically apparent liver injury have emerged, primarily in bodybuilders. The European Food Safety Authority has not established the safety of Tongkat Ali for any condition of use, citing concerns.
  • Genotoxicity (DNA Damage): An analysis found that high intakes of a water-based extract could lead to DNA damage in tissues of the stomach and duodenum in some studies.
  • Prostate Changes: Animal studies show that high intakes of Eurycoma longifolia can cause significant increases in prostate size and lead to abnormal cell proliferation, raising concerns about prostate health with prolonged, high-intake use.

Drug Interactions and Contraindications

Tongkat Ali can interact with various medications and is contraindicated for people with certain health conditions.

  • Medications: Significant interactions have been identified with immunosuppressants, diabetes medications (risk of hypoglycemia), blood thinners (like warfarin), and certain blood pressure drugs (like propranolol).
  • Contraindications: Individuals with hormone-sensitive cancers (prostate or breast cancer), diabetes, heart disease, liver or kidney disease, or sleep apnea should avoid this supplement.
  • Pregnancy and Breastfeeding: Lack of reliable information means pregnant and breastfeeding women should avoid use.

The Problem of Supplement Quality and Contamination

A major risk factor is the lack of regulation in the dietary supplement industry. This can lead to products that are mislabeled, contain different concentrations than advertised, or are contaminated with dangerous substances.

  • Heavy Metal Contamination: Studies have found high levels of mercury and lead in some Tongkat Ali products, which can cause heavy metal poisoning.
  • Adulteration with Prescription Drugs: Some supplements marketed as Tongkat Ali have been found to contain undisclosed sildenafil (Viagra) analogs, which can pose significant health threats, especially for those with heart conditions.

Comparison of Side Effects: Tongkat Ali vs. Ginseng

Feature Tongkat Ali (Long Jack) Ginseng (Panax Ginseng)
Primary Function Increases testosterone, libido, and energy. Adaptogen, immunity, mental/physical performance.
Mental/Behavioral Effects Anxiety, restlessness, insomnia, increased aggression. Nervousness, excitement, insomnia, mood changes.
Gastrointestinal Effects Nausea, abdominal discomfort, diarrhea. Upset stomach, diarrhea.
Cardiovascular Effects Potential increase in heart rate and blood pressure with high intake. Can increase or decrease blood pressure; risk of irregular heart rhythm.
Hormonal Effects Increases testosterone levels. Contains estrogen-like compounds, caution with hormone-sensitive conditions.
Liver Concern Rare reports of liver injury. Rare reports of liver damage.
Drug Interactions Immunosuppressants, blood thinners, diabetes, blood pressure meds. Blood thinners (warfarin), diabetes meds, MAOIs, stimulants.
Quality Concerns Not regulated, high risk of contamination with heavy metals or drugs. Also requires purchasing from reputable sources due to variable quality.

How to Mitigate Risks When Using Herbal Supplements

If you choose to use Tongkat Ali or other herbal supplements, there are steps you can take to minimize your risk of adverse effects.

  • Consult a Healthcare Provider: Always speak with a doctor before starting a new supplement, especially if you have existing health conditions or take other medications.
  • Start with a Low Intake: Begin with a very low intake to assess your body's tolerance before gradually increasing.
  • Purchase from a Reputable Source: Choose a brand that uses third-party testing to verify purity and potency, reducing the risk of contamination.
  • Monitor Your Body's Reaction: Be aware of any changes in mood, energy, or digestion and stop use if adverse symptoms occur.
  • Avoid Use in Certain Conditions: If you have a serious medical condition, such as liver disease or cancer, the risks likely outweigh the unproven benefits.

Conclusion

While Tongkat Ali is marketed for its performance and vitality-enhancing effects, users must be aware of the potential for negative side effects. These can range from mild issues like digestive upset and insomnia to more serious concerns such as liver injury and potential DNA damage with higher intake. Unregulated supplement quality poses additional risks of heavy metal contamination and adulteration with pharmaceutical drugs. It is critical to prioritize safety by consulting a healthcare professional, choosing high-quality, tested products, and being attentive to your body's response. Making an informed decision based on known risks and personal health status is the best approach to nutritional supplementation.

Frequently Asked Questions

Yes, some users report experiencing anxiety and restlessness, likely due to the supplement's effects on hormones and energy levels. These symptoms may be more noticeable with higher intake.

Rare cases of liver injury have been reported in individuals taking Tongkat Ali, though the link is not definitively proven and some cases involved other substances. Caution is advised, especially for those with pre-existing liver conditions.

Tongkat Ali can increase heart rate and blood pressure, especially with higher intake. It is not recommended for individuals with high blood pressure, and those on related medication should exercise caution and consult a doctor.

Tongkat Ali can interact with several medications, including blood thinners, immunosuppressants, and drugs for diabetes and high blood pressure. It is crucial to consult a healthcare professional before combining it with any prescription medication.

Yes, supplement quality is a significant concern due to lack of regulation. Some products have been found to be contaminated with heavy metals like mercury and lead, or adulterated with undisclosed drugs.

There is no consensus on a single typical intake, and suitable intake can vary. Starting with a low intake is often advised, but consulting a healthcare provider is the safest approach, especially for long-term use.

Certain populations should avoid Tongkat Ali, including pregnant and breastfeeding women, children, and individuals with hormone-sensitive cancers, diabetes, heart disease, liver disease, kidney disease, or sleep apnea.

References

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Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.